Synthesis, Characterization, and CT-DNA Interactions of Novel Complexes of ( Copper(II)\ Tetradentate SNNS Schiff Bases)

This research focuses on synthesis of novel N-donor ligand, which are expected to be excellent chelator in coordination chemistry and synthesis of their complexes. In part one, novel heterocyclic compound L1 was synthesized by solvent-free condensation reaction of 5-bromothiophene-2-carbaldehyde with 2,2-dimethyl-1,3-propanediamine at mild condition. The desired product was characterized by FT-IR spectroscopy, X-ray single crystal diffraction, elemental analysis, TG\DTG, UV-visible spectroscopy, and 1H NMR spectroscopy. The binding ability of the new L1 was evaluated using CuX2 salt, X = Br, Cl, OAc, to form complex 1,2 and 3 Penta coordination around Cu(II) centers was characterized usinFT- IR spectroscopy and TG/DTG analysis. In part two, novel Schiff base; L2 was also synthesized directly by mixing of thiophene-2-carbaldehyde with cyclohexane-1,2-diamine in ultrasonic path. The desired product was characterized by FT-IR spectroscopy,13C-NMR 1H NMR spectroscopy, cyclic voltammetry, thermal analysis. The desired Schiff base was used as tetradentate (N2S2) chelate ligand when coordinate with CuX2. The Cu(II) complexes4, 5 and 6 formed by mixing 1:1 Schiff base with Cu(II) was confirmed spectrally to be square pyramide dicationic complexes with one H2O.