Synthesis and Biological Activity of New Heterocyclic Schiff Bases

A series of novel biologically active hydrazides -hydrazone Schiff base were synthesized from various types of heterocyclic carbonyl compounds and amino groups of heterocyclic hydrazides using ethanol as a solvent. Such Schiff bases have general formula: R1N=CHR2. In which R1 and R2 are: 2-amino-3-methylpyridine, nicotinic hydrazide, 2-furoic hydrazide, 2-amino-5-bromopyridine, salicoylhydrazides, dipyridyl ketone, pyridin-2-carbaldehyde, furfural, 2-thiophene-carbaldehyde, 5-bromo-2-thiophene-carboxaldehyde, respectively. Such compounds were characterized by various physiochemical techniques such as melting point, elemental analysis, FT- IR, UV-visible, TG/DTG, 1H and 13C NMR spectroscopy.