Novel cationic water solublepolynitrogen/copper (II) complexes as a new antimicrobial therapy

The six dicationic water soluble copper(II) complex1, complex2 complex3, complex4, complex5 and complex6, of general formula [CuNNN(NN)]Br2 [NNN = triamine and NN is chda = 1,2-diamiocyclohexane or Me2pn = 2,2dimethyl-1,3diamino propane] were prepared under ultrasonic mode with very good yield. These complexes were characterized by elemental microanalysis, UV-visible and IR spectroscopy. It was found that four complexes (complex1, complex3, complex4, complex5) of the six complexes have a high antimicrobial activity against Klebsiella, Escherichia coli, Proteus and Staphylococcus aureus. Complex2 have a little antimicrobial activity. Complex6 have not any antimicrobial activity at any kind of the used bacteria, this could be because the complex is unstable. The antibiotic Cephalexin was used as a standard to compare the antibacterial activity of the six complexes against the bacteria. Cephalexin used as antibacterial drug to kill Gram-positive and Gram-negative bacteria. The antibacterial activity of the complexes1,3,4,5 against the bacteria were better than Cephalexin. Also the complexes 1,3,4,5 showed a high antimicrobial activity against Klebsiella compared with Cephalexin that have not any antibacterial activity against this kind of bacteria, which encourages to use these complexes as a topical treatment instead of Cephalexin.