Cur Cumin Based Herero Cycles With Possible Dual Action Antibacterial Activity

A new series of curcumin and tetrahydrocurcumin (THC) based diazepines were synthesized. Tetrahydrocurcumin was prepared by hydrogenation of curcumin using Pd/C as a catalyst. Synthesis of the diazepines was carried out by a new method. In this method, curcumin or tetrahydrocuccumin is dissolved in ethanol then reacted with various aromatic diamino compounds in presence of catalytic amount of concentrated sulfuric acid. The prepared diazepines were purified by Flash chromatography or crystallization in water-Ethanol solution. Then were characterized by various spectroscopic techniques such as MS, FT-IR, 13C and 1H NMR spectroscopy. The prepared diazepinesare expected to have excellent antibacterial activity since, in a previous study, it has been shown that diazepine (figure below) made from curcumin and ethylene diamine exhibitedremarkablepotencyagainstGrampositive bacteriaS. aureus. The antibacterial activity of the prepared diazepinesagainst four different types of bacteria Staphylococcus aureus, Escherichia coli, Proteus mirabilis and Pseudomonas aeruginosa will be evaluated in a future work.