Biodegradable Poly (dl-lactide-co-glycolide) Microcapsules as a Drug Delivery System

Year: 
2014
Discussion Committee: 
Dr. Mohammed Suleiman/ Supervisor
Dr. Hassan Sawalha/ Co-Supervisor
Dr. Ziad Al-shakhshir/ External Exa
Dr. Nizar Matar/ Internal Examiner
Supervisors: 
Dr. Mohammed Suleiman/ Supervisor
Dr. Hassan Sawalha/ Co-Supervisor
Authors: 
Younis Abed Younis Abu Ain
Abstract: 
Poly dl-lactide co-glycolide (PLG) is a biodegradable polymer that has a slow degradation rate and high permeability to small drug molecules. PLG microcapsules were prepared by emulsifying a polymer solution that consists of PLG/solvent (dichloromethane) into a continuous phase that consists of a nonsolvent solution (water and SDS as a surfactant). After emulsification, the solvent diffuses out of polymer droplets (liquid microcapsules) to the nonsolvent solution and then evaporates at the surface of the nonsolvent to the air. The encapsulation of the limonene within the polymer microcapsules was prepared, and limonene release was determined with time from polymer microcapsules prepared. The current study aims at studying the effect of the type of the nonsolvnet on the drug release behavior (i.e. kinetics) out of the microcapsules in relation with the properties of the polymer shell. The drug release from the solid microcapsules was measured using spectroscopic techniques. The size of microcapsules was analyzed by optical light microscope. The PLG microcapsules were prepared by emulsifying the polymer solution in continuous phase. The two phases were mixed for at least 2 hr using a magnetic stirrer; the size of prepared microcapsules was measured by the light microscope. The PLG microcapsules were prepared using different concentrations of SDS solution, methanol, and ethanol and study of its impact on the size of the PLG microcapsules. Our results show that as the concentration of nonsolvent increases in the process of preparing of PLG microcapsules the size of prepared microcapsules decreases and the limonene release increases from polymer microcapsules with decreasing the size of microcapsules. These results can be explained as follows: with increasing the concentration of methanol, ethanol or SDS, the viscosity of the nonsolvent increases and the interfacial tension decreases. This lead to a decrease in size of obtained PLG microcapsules and smaller microcapsules are obtained.
Pages Count: 
73
Status: 
Published