Complexes Design, Spectral, Structural and Biological Activities of Novel dicationic [Copper(II)1,10-phenanthrolineN-tridentate] 2bromide

Four novel new monocationic and dicationic mixed copper(II) complexes, of general formula [Cu(1,10-phen)(dien)]Br2 (1), [Cu(1,10-phen) (dipn)] Br2(2), [Cu(2.2'-dpa)2Cl]Cl(3) and [Cu(2.2'-dpa)(dien)]Cl2(4) [phen=phenanthroline, dien=Diethylenetriamine, dipn=Diproplenetriamine, and dpa=Dipyridylamine], synthesized in very good yields. These complexes were characterized by spectroscopic, elemental analysis, UV-visible, IR-Spectroscopy, thermal analysis TGA/DTA and X-ray crystallographic techniques. Single crystal X-ray diffraction data for complex 1 showed a distorted square pyramidal geometry around Cu(II) ion with three solvated water molecules and complex 3 the same distorted square pyramidal geometry around Cu(II) ion. Biological studies of Antioxidant, Antimicrobials, Antifungal assays and Cytotoxicity and CT-DNA binding were conducted to evaluate the biological activities of complex 1, 2. These complexes exhibit a promising antimicrobial effect against an array of microbes at 200µg/mL concentration. The antiproliferative assay shows a high potential of these complexes to target Human keratinocyte cell line with IC50 values of 155 and 152µM. The CT-DNA binding of complex 1 was evaluated using electronic absorption spectroscopy at max = 620nm, such complexes showed high DNA binding, the value of binding constant (Kb = 8.6×104 M1)which in verygood range. The biological activities of complex 1 and complex 2 have shown new chemotherapy, antimicrobial, high DNA binding, and high anticancer activities The theoretical absorption spectra of complex 1 and 3 in water were modeled by time-dependent density functional theory (TD-DFT) using Gaussian program.