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Drug Optimization & Chemical Structure Modification of Antiseizure

Conference: 
The Fifth Palestinian International Chemistry Conference
Authors: 
Walaa Hemedat
Abstract: 

Gabapentin which is chemically known as 1-aminomethyl-1-cyclohexaneacetic acid and its structure is shown below is a very well known pharmaceutical drug useful for the treatment of epilepsy and other cerebral disorders. The medicine suffers form several disadvantages and low bioactivity. This presentation covers an overview about the drug synthesis, application and new ways of structure modification that could enhance the bioactivity of Gabapentin and reduces it side effects. The suggested chemical modification of Gabapentin is expected to increase its permeability to blood brain barrier.

Full Text: 
PDF icon Drug Optimization & Chemical Structure Modification of Antiseizure