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Electrophysiological Assessments of Time- Course Effects on Diabetic peripheral Neuropathy and Their Correlation to the Current Hypotheses

Journal: 
An-Najah University Journal for Research - Natural Sciences - Volume 15, Issue 1, 2001
Start Page: 
63
End Page: 
79
Received: 
Saturday, August 19, 2000
Accepted: 
Saturday, September 1, 2001
Authors: 
I. W. Muflih*
A. M. Abdul-Kareem**
G. A. Al-Sharify***
Abstract: 

Diabetes mellitus patients (number = 228) of insulin dependent (IDDM, two groups) and non- insulin dependent (NIDDM, two groups) were enrolled in the present study. Each of the two groups of the patients were comprising a group of less than ten years and another group of more than ten years duration of the disease. Seven peripheral nerves were tested electrophysiologically for their latency, velocity and amplitude. The obtaiened results showed significant differences between the two types of the disease durations. Measurments in terms of increased latencies with reduction in the sensory and motor conductive velocities, along with reduction in amplitudes were found more evident in diabetic patients with more than ten years duration in comparison to patients of less than ten years duration of the disease. The obtained results of the present work suggests a recommendation for the mixed metabolic- vascular pathogenesis hypothesis that concern the diabetic neuropathy. Key words: Time – course effects on diabetic neuropathy

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